Sakamoto A, Ido T
Division of Radiopharmaceutical Chemistry, Tohoku University, Sendai, Japan.
Brain Res. 1993 Nov 26;629(1):171-5. doi: 10.1016/0006-8993(93)90499-d.
To determine whether sulfatide liposomes can cross the blood-brain barrier (BBB) with or without osmotic treatment by mannitol, we administered liposomes through the internal carotid artery in rats. Sulfatide liposomes could pass the BBB with osmotic treatment, but not without osmotic treatment. Therefore, we propose that the combination method of administration of the reticuloendothelial-system avoiding liposomes with osmotic treatment can be useful for treatment of various kinds of brain diseases.
为了确定硫苷脂脂质体在有或没有甘露醇渗透治疗的情况下能否穿过血脑屏障（BBB），我们通过大鼠颈内动脉给予脂质体。硫苷脂脂质体在有渗透治疗时可以穿过血脑屏障，但在没有渗透治疗时则不能。因此，我们提出，网状内皮系统规避脂质体与渗透治疗相结合的给药方法可能对治疗各种脑部疾病有用。
