使用抗性供体对小鼠逆转录病毒诱导的白血病进行骨髓移植治疗。
Bone marrow transplantation therapy using resistant donors for retrovirus-induced leukaemia in mice.
作者信息
Iwai H, Day N K, Hamada N, Inaba M M, Ikehara S, Good R A
机构信息
Department of Otorhinolaryngology, Kansai Medical University, Osaka, Japan.
出版信息
Clin Exp Immunol. 1994 Jan;95(1):135-40. doi: 10.1111/j.1365-2249.1994.tb06027.x.
Infection with Rauscher leukaemia virus (RLV) causes erythroleukaemia, anaemia, viraemia, and splenomegaly, features which develop very quickly in mice of strains susceptible to RLV but more slowly or not at all in strains resistant to RLV. We compared the effects of bone marrow transplantation (BMT) of donor cells obtained from a mouse strain resistant to the virus with the effects of BMT of donor cells obtained from strains susceptible to the virus, in recipient virus-susceptible mice which had previously been inoculated with RLV. Our results indicated that bone marrow transplantation from a marrow-resistant donor, but not from a susceptible donor, delayed the expression of leukaemia and delayed death, although such treatment did not appear to inhibit viral infection in susceptible recipients.
劳舍尔白血病病毒（RLV）感染会引发红白血病、贫血、病毒血症和脾肿大，这些特征在对RLV敏感的小鼠品系中发展得非常迅速，但在对RLV有抗性的品系中发展得较慢或根本不发展。我们比较了从对该病毒有抗性的小鼠品系获得的供体细胞进行骨髓移植（BMT）与从对该病毒敏感的品系获得的供体细胞进行BMT，对先前已接种RLV的病毒敏感受体小鼠的影响。我们的结果表明，来自骨髓抗性供体而非敏感供体的骨髓移植，延缓了白血病的表达并延迟了死亡，尽管这种治疗似乎并未抑制敏感受体中的病毒感染。
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