通过X射线诱导的染色体损伤解析甲氨蝶呤阻断的细胞周期阶段特异性。
Cell-cycle-stage specificity of the methotrexate block as resolved by X-ray-induced chromosome damage.
作者信息
Richardson V B, Littlefield L G, Sayer A M, Peterson P T
机构信息
Department of Biology, Tuskegee University, AL 36088.
出版信息
Cytogenet Cell Genet. 1994;66(2):126-8. doi: 10.1159/000133682.
PMID:8287684
Abstract
Radiation-induced chromosome aberrations were used as biomarkers to compare G0, mid-G1, and methotrexate (MTX)-arrested lymphocytes. The ratio of chromosome-type to chromatid-type aberrations in MTX-arrested cells was consistent with that predicted when postreplicative chromosomes are exposed to ionizing radiation and supports the premise that MTX arrests cells in late S/G2 of the cell cycle.
摘要
辐射诱导的染色体畸变被用作生物标志物，以比较G0期、G1期中期和甲氨蝶呤（MTX）阻滞的淋巴细胞。MTX阻滞细胞中染色体型畸变与染色单体型畸变的比例，与复制后染色体暴露于电离辐射时预测的比例一致，并支持MTX将细胞阻滞在细胞周期S期晚期/G2期的前提。
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