Matusiewicz S P, Williamson I J, Sime P J, Brown P H, Wenham P R, Crompton G K, Greening A P
Respiratory Unit, Western General Hospital, Edinburgh, Scotland, UK.
Eur Respir J. 1993 Oct;6(9):1282-6.
Total plasma lactate dehydrogenase (LDH) activity may be elevated in cryptogenic fibrosing alveolitis (CFA) and extrinsic allergic alveolitis (EAA), and may be a useful monitor of disease progress. In a retrospective, primary referral centre study, we compared LDH at presentation, prior to bronchoalveolar lavage BAL, and after treatment and follow-up with changes in pulmonary function, in patients with CFA, EAA and pulmonary sarcoidosis. Plasma levels of LDH at presentation in CFA (n = 47) and EAA (n = 10) were significantly higher than in patients with sarcoidosis (n = 36). LDH activity decreased in patients with improving lung function (EAA, p = 0.008; CFA, p = 0.02), whereas it increased in CFA patients with deteriorating lung function (p = 0.015). Total plasma LDH is a simple, though nonspecific test, which appears to reflect changes of disease activity in patients with CFA and EAA.
在隐源性纤维性肺泡炎（CFA）和外源性过敏性肺泡炎（EAA）中，血浆总乳酸脱氢酶（LDH）活性可能会升高，并且可能是疾病进展的有用监测指标。在一项回顾性的初级转诊中心研究中，我们比较了CFA、EAA和肺结节病患者在支气管肺泡灌洗（BAL）前就诊时、治疗及随访后的LDH水平与肺功能变化情况。CFA组（n = 47）和EAA组（n = 10）就诊时的血浆LDH水平显著高于结节病患者（n = 36）。肺功能改善的患者（EAA，p = 0.008；CFA，p = 0.02）LDH活性降低，而CFA组中肺功能恶化的患者LDH活性升高（p = 0.015）。血浆总LDH是一项简单但非特异性的检测，似乎能反映CFA和EAA患者疾病活动的变化。
