由全长tau蛋白组装成阿尔茨海默氏样细丝。
Assembly of Alzheimer-like filaments from full-length tau protein.
作者信息
Crowther R A, Olesen O F, Smith M J, Jakes R, Goedert M
机构信息
Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
出版信息
FEBS Lett. 1994 Jan 10;337(2):135-8. doi: 10.1016/0014-5793(94)80260-2.
PMID:8287967
Abstract
The principal fibrous component of neurofibrillary pathology in Alzheimer's disease, the paired helical filament, is formed from hyperphosphorylated microtubule-associated protein tau. Here we show that recombinant tau protein either in a non-phosphorylated state or following phosphorylation with brain extract can be assembled in vitro into filaments resembling those seen in Alzheimer's disease.
摘要
阿尔茨海默病神经原纤维病变的主要纤维成分——双螺旋丝，是由过度磷酸化的微管相关蛋白tau形成的。我们在此表明，无论是处于非磷酸化状态的重组tau蛋白，还是经脑提取物磷酸化后的重组tau蛋白，都能在体外组装成与阿尔茨海默病中所见细丝相似的细丝。
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