Tabandeh H, Gopal S, Teimory M, Wolfensberger T, Luke I K, Mackie I, Dilly N
Department of Ophthalmology, St George's Hospital, London, UK.
Eye (Lond). 1993;7 ( Pt 5):648-51. doi: 10.1038/eye.1993.148.
Acanthosis nigricans classically presents with pigmented skin lesions over the neck, groin and axillae. It may involve the mucosal surfaces, particularly the oral mucosa. Conjunctival involvement is very rare, especially in the variety associated with malignancy. We report a case of acanthosis nigricans associated with squamous cell carcinoma of the bronchus where bilateral papillary conjunctivitis, progressing to hypertrophic papillary conjunctival and lid margin lesions, was the presenting feature. Topical treatment with corticosteroid and artificial tear drops resulted in the partial improvement of the ocular symptoms.
黑棘皮病的典型表现是颈部、腹股沟和腋窝出现色素沉着性皮肤病变。它可能累及黏膜表面，尤其是口腔黏膜。结膜受累非常罕见，特别是在与恶性肿瘤相关的类型中。我们报告一例与支气管鳞状细胞癌相关的黑棘皮病病例，其表现特征为双侧乳头性结膜炎，进而发展为肥厚性乳头性结膜和睑缘病变。局部使用皮质类固醇和人工泪液治疗使眼部症状部分改善。
