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微小膜壳绦虫感染大鼠小肠代谢改变的核磁共振氢谱研究

1H NMR study of metabolic alterations in the small intestine of rats infected with Hymenolepis diminuta.

作者信息

Novak M, Hudspeth C, Blackburn B J

机构信息

Department of Biology, University of Winnipeg, Manitoba, Canada.

出版信息

Int J Biochem. 1993 Nov;25(11):1587-91. doi: 10.1016/0020-711x(93)90516-h.

DOI:10.1016/0020-711x(93)90516-h
PMID:8288027
Abstract

1H NMR spectra of the duodenum, jejunum and ileum tissues of the small intestine of a rat showed metabolic gradients. 2. The concentrations of metabolites in these gut regions were altered by the presence of the tapeworm Hymenolepis diminuta. 3. In the infected duodenum there was significantly less glycogen, glucose and phosphocreatine/creatine, but significantly more lactate than in the corresponding controls. 4. Infected jejunum contained significantly less betaine but significantly more succinate, alanine and lactate. 5. Infected ileum had significantly less glycogen and taurine but significantly more alanine and lactate.

摘要
  1. 大鼠小肠十二指肠、空肠和回肠组织的1H核磁共振谱显示出代谢梯度。2. 微小膜壳绦虫的存在改变了这些肠道区域中代谢物的浓度。3. 与相应的对照组相比,受感染的十二指肠中糖原、葡萄糖和磷酸肌酸/肌酸的含量显著降低,但乳酸含量显著增加。4. 受感染的空肠中甜菜碱含量显著降低,但琥珀酸、丙氨酸和乳酸含量显著增加。5. 受感染的回肠中糖原和牛磺酸含量显著降低,但丙氨酸和乳酸含量显著增加。

相似文献

1
1H NMR study of metabolic alterations in the small intestine of rats infected with Hymenolepis diminuta.微小膜壳绦虫感染大鼠小肠代谢改变的核磁共振氢谱研究
Int J Biochem. 1993 Nov;25(11):1587-91. doi: 10.1016/0020-711x(93)90516-h.
2
The spatial and temporal concentrations of choline in the lumen contents of the small intestine of uninfected and Hymenolepis diminuta infected rats.未感染和感染微小膜壳绦虫的大鼠小肠肠腔内容物中胆碱的时空浓度。
Comp Biochem Physiol A Mol Integr Physiol. 1998 Aug;120(4):705-11. doi: 10.1016/s1095-6433(98)10090-9.
3
Hymenolepis diminuta: effect on the oxidation-reduction potential in the mammalian gastrointestinal canal.
Exp Parasitol. 1975 Apr;37(2):223-32. doi: 10.1016/0014-4894(75)90074-0.
4
Hymenolepis diminuta fractions but not previous tapeworm infection stimulate intestinal myoelectric alterations in vivo in the rat.微小膜壳绦虫提取物而非既往的绦虫感染可刺激大鼠体内肠道肌电改变。
J Parasitol. 1998 Aug;84(4):673-80.
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Hymenolepis diminuta: acidification and bicarbonate absorption in the rat intestine.
Exp Parasitol. 1975 Feb;37(1):1-14. doi: 10.1016/0014-4894(75)90048-x.
6
Intestinal contractions and migration behaviour in Hymenolepis diminuta.微小膜壳绦虫的肠道收缩与迁移行为
Int J Parasitol. 1992 Sep;22(6):813-7. doi: 10.1016/0020-7519(92)90132-5.
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Hymenolepis diminuta: migration, and the rat host's intestinal and blood plasma glucose levels following dietary carbohydrates intake.微小膜壳绦虫:在摄入膳食碳水化合物后其迁移情况以及大鼠宿主的肠道和血浆葡萄糖水平
Exp Parasitol. 1977 Feb;41(1):213-28. doi: 10.1016/0014-4894(77)90147-3.
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Small intestinal transections decrease the occurrence of tapeworm-induced myoelectric patterns in the rat.小肠横断术可降低大鼠中绦虫诱导的肌电模式的发生率。
Neurogastroenterol Motil. 2002 Aug;14(4):349-56. doi: 10.1046/j.1365-2982.2002.00339.x.
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Myoelectric response of the small intestine to the orad presence of the tapeworm Hymenolepis diminuta.小肠对微小膜壳绦虫口腔前端存在的肌电反应。
J Parasitol. 2001 Dec;87(6):1255-9. doi: 10.1645/0022-3395(2001)087[1255:MROTSI]2.0.CO;2.
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Hymenolepis diminuta: analysis of the expression of Toll-like receptor genes (TLR2 and TLR4) in the small and large intestines of rats. Part II.微小膜壳绦虫:Toll 样受体基因(TLR2 和 TLR4)在大鼠小肠和大肠表达的分析。第二部分。
Exp Parasitol. 2013 Oct;135(2):437-45. doi: 10.1016/j.exppara.2013.08.002. Epub 2013 Aug 27.

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