Huang S W, Kao K J
Department of Pediatrics, University of Florida College of Medicine, Gainesville.
Allergy Proc. 1993 Sep-Oct;14(5):357-61. doi: 10.2500/108854193778774074.
The tests currently used to monitor atopic dermatitis in children--serum IgE level and eosinophil count--are not sensitive enough to accurately track the course of the disease. Because previous studies have shown that atopic dermatitis is an inflammatory disease and because our previous work has shown that plasma thrombospondin level correlates well with the course of other inflammatory diseases, we conducted this study to determine the relationship between plasma thrombospondin level and the severity of skin inflammation in children with atopic dermatitis. Eosinophil count, serum IgE level, and plasma thrombospondin level were measured in 48 children with atopic dermatitis at onset of flare-up, 2 weeks after treatment started, and 2 months after treatment started. The results of all three tests were better after 2 months of therapy than they had been at the initial visit, but only plasma thrombospondin level showed a statistically significant decrease, which coincided with clinical improvement. Plasma thrombospondin level seems to correlate with the clinical course of patients with atopic dermatitis better than do serum IgE level or eosinophil count.
目前用于监测儿童特应性皮炎的检测方法——血清IgE水平和嗜酸性粒细胞计数——不够灵敏，无法准确追踪疾病进程。由于先前的研究表明特应性皮炎是一种炎症性疾病，且我们之前的工作表明血浆血小板反应蛋白水平与其他炎症性疾病的进程密切相关，因此我们开展了这项研究，以确定血浆血小板反应蛋白水平与特应性皮炎患儿皮肤炎症严重程度之间的关系。对48例特应性皮炎患儿在病情发作时、治疗开始2周后和治疗开始2个月后进行嗜酸性粒细胞计数、血清IgE水平和血浆血小板反应蛋白水平检测。治疗2个月后，所有三项检测结果均比初次就诊时有所改善，但只有血浆血小板反应蛋白水平出现了具有统计学意义的下降，这与临床改善情况相符。血浆血小板反应蛋白水平似乎比特应性皮炎患者的血清IgE水平或嗜酸性粒细胞计数更能反映其临床病程。
