[Pharmacokinetic studies on 99mTc-NGA in human].

Two normal subjects and three patients with hepatic disease were intravenously injected each with a single dose of 99mTc-NGA (galactosyl-neoglycoalbumin), a liver receptor imaging agent. The results showed that pharmacokinetics of 99mTc-NGA accorded with the two compartment open model. In the normal subjects, T1/2 alpha and T1/2 beta averaged 1.65 and 19.39 min respectively, indicating a rapid distribution process and a slow elimination process. There were significant differences in pharmacokinetics of 99mTc-NGA between the normal subjects and the patients with hepatic disease, and therefore the relevant parameters are of importance for the evaluation of hepatic function.