Guan C, Chen Q, Tan T
Hua Xi Yi Ke Da Xue Xue Bao. 1993 Sep;24(3):268-70.
Two normal subjects and three patients with hepatic disease were intravenously injected each with a single dose of 99mTc-NGA (galactosyl-neoglycoalbumin), a liver receptor imaging agent. The results showed that pharmacokinetics of 99mTc-NGA accorded with the two compartment open model. In the normal subjects, T1/2 alpha and T1/2 beta averaged 1.65 and 19.39 min respectively, indicating a rapid distribution process and a slow elimination process. There were significant differences in pharmacokinetics of 99mTc-NGA between the normal subjects and the patients with hepatic disease, and therefore the relevant parameters are of importance for the evaluation of hepatic function.
给两名正常受试者和三名肝病患者静脉注射单剂量的肝受体显像剂99mTc-NGA（半乳糖基新糖白蛋白）。结果表明，99mTc-NGA的药代动力学符合二室开放模型。在正常受试者中，T1/2α和T1/2β平均分别为1.65分钟和19.39分钟，表明分布过程迅速而消除过程缓慢。正常受试者与肝病患者之间99mTc-NGA的药代动力学存在显著差异，因此相关参数对肝功能评估具有重要意义。
