Buetow K H, Duggan D, Yang B, Ludwigsen S, Puck J, Porter J, Budarf M, Spielman R, Emanuel B S
Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
Genomics. 1993 Nov;18(2):329-39. doi: 10.1006/geno.1993.1473.
Utilizing the CEPH (Centre d'Etude du Polymorphism Humain) reference panel and genotyping data for 24 simple tandem repeat polymorphism (STRP) markers, we have constructed a 15-locus multipoint genetic framework map of human chromosome 22. The markers form a continuous linkage group of 51 cM in males and 81 cM in females. Likely genetic locations are provided for 9 additional STRP sequences. The map was constructed employing the CRIMAP computational methodology to build the multipoint map via a stepwise algorithm. The quality of the framework map was evaluated using a battery of statistical diagnostics that suggest a typing error frequency of 0.1% for markers within the map.
利用人类多态性研究中心（CEPH）参考面板以及24个简单串联重复多态性（STRP）标记的基因分型数据，我们构建了人类22号染色体的一个15位点多点遗传框架图谱。这些标记在男性中形成了一个51厘摩（cM）的连续连锁群，在女性中形成了一个81厘摩的连续连锁群。还给出了另外9个STRP序列的可能遗传位置。该图谱是采用CRIMAP计算方法，通过逐步算法构建多点图谱而成。利用一系列统计诊断方法对框架图谱的质量进行了评估，结果表明图谱中标记的分型错误频率为0.1%。
Zotero 插件