Tontsch U, Rott O
Max-Planck-Institute for Psychiatry, Department of Neuroimmunology, Martinsried, Germany.
Int Immunol. 1993 Mar;5(3):249-54. doi: 10.1093/intimm/5.3.249.
Astrocytes have been shown to act as potent accessory cells for MHC class II-restricted T cell responses in vitro after treatment with interferon-gamma. In contrast, even under conditions of severe central nervous system (CNS) inflammation, they seem to express little, if any, class II molecules in vivo. Thus the role of astroglial cells as accessory cells in immune responses in the CNS remains to be determined. We have studied neuron--glia interactions with respect to induction of MHC class II molecules. Surprisingly, in a co-culture system, viable neurons inhibited the induction of class II restriction elements on astrocytes. This effect was only observed when neurons had contact to astrocytes; neuron derived soluble factors alone were insufficient. Most interestingly, the suppressive effect of neurons on class II inducibility operated specifically on astrocytes, while microglial cells were left unaffected.
已证明，经γ干扰素处理后，星形胶质细胞在体外可作为MHC II类限制性T细胞反应的有效辅助细胞。相比之下，即使在严重的中枢神经系统（CNS）炎症条件下，它们在体内似乎也很少表达（如果有表达的话）II类分子。因此，星形胶质细胞作为CNS免疫反应中辅助细胞的作用仍有待确定。我们研究了神经元与神经胶质细胞在诱导MHC II类分子方面的相互作用。令人惊讶的是，在共培养系统中，活神经元抑制了星形胶质细胞上II类限制性元件的诱导。只有当神经元与星形胶质细胞接触时才观察到这种效应；仅神经元衍生的可溶性因子是不够的。最有趣的是，神经元对II类诱导性的抑制作用特异性地作用于星形胶质细胞，而小胶质细胞则不受影响。
