Snyder D S, Unanue E R
J Immunol. 1982 Nov;129(5):1803-5.
Corticosteroids have profound effects on functions of the macrophage associated with antigen presentation to T cells. The drugs inhibited the expression of surface I-region-associated (Ia) antigens by peritoneal macrophages both in vitro and in vivo, reduced the production of IL 1, and inhibited antigen presentation for T cell proliferation by macrophages. The doses of hydrocortisone and prednisolone that inhibited by 50% Ia expression in cultured macrophages ranged around 2 to 5 x 10(-8) M. These results could explain one mechanism by which corticosteroids suppress the induction of immune responses.
皮质类固醇对与向T细胞呈递抗原相关的巨噬细胞功能有深远影响。这些药物在体外和体内均抑制腹膜巨噬细胞表面I区相关（Ia）抗原的表达，减少白细胞介素1的产生，并抑制巨噬细胞向T细胞增殖呈递抗原。在培养的巨噬细胞中抑制50% Ia表达的氢化可的松和泼尼松龙剂量范围约为2至5×10（-8）M。这些结果可以解释皮质类固醇抑制免疫反应诱导的一种机制。
