Thurmond M C, Jameson C M, Picanso J P
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
J Am Vet Med Assoc. 1993 Dec 1;203(11):1576-8.
A prospective clinical trial was conducted on 2 large dairies in the San Joaquin Valley of California to determine whether a single intrauterine infusion with procaine penicillin G or oxytetracycline reduced the calving-to-conception interval in cows with endometritis. Cows with endometritis were randomly assigned to a treatment or a control group. The uterus of treated cows on 1 dairy was infused with 0.8 to 1.0 million U of procaine penicillin G in 40 ml of sterile water, and the uterus of treated cows on the other dairy was infused with 500 mg of oxytetracycline in 20 ml of sterile water, both of which were typical doses used on dairies in the area. A difference was not observed in the cumulative proportion of cows remaining nonpregnant between 87 penicillin-treated and 77 control cows on the 1 dairy (P = 0.356), or between 74 oxytetracycline-treated and 62 control cows on the other dairy (P = 0.174). Results suggest that routine infusion of antibiotics to treat endometritis, as commonly practiced, may not be efficacious.
在加利福尼亚州圣华金河谷的2个大型奶牛场进行了一项前瞻性临床试验，以确定单次子宫内注入普鲁卡因青霉素G或土霉素是否能缩短子宫内膜炎奶牛的产犊至受孕间隔。患有子宫内膜炎的奶牛被随机分配到治疗组或对照组。一个奶牛场中接受治疗的奶牛子宫被注入40毫升无菌水中含有的80万至100万单位普鲁卡因青霉素G，另一个奶牛场中接受治疗的奶牛子宫被注入20毫升无菌水中含有的500毫克土霉素，这两种都是该地区奶牛场常用的典型剂量。在一个奶牛场的87头接受青霉素治疗的奶牛和77头对照奶牛之间，以及另一个奶牛场的74头接受土霉素治疗的奶牛和62头对照奶牛之间，未观察到未怀孕奶牛累积比例的差异（P = 0.356和P = 0.174）。结果表明，按照常规做法对子宫内膜炎进行抗生素灌注可能无效。
