Woods P R, Gossett R E, Jain N C, Smith R, Rappaport E S, Kasari T R
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843-4475.
J Am Vet Med Assoc. 1993 Dec 1;203(11):1579-82.
In a 2-month-old crossbred calf with paraplegia, results of neurologic evaluation were suggestive of a spinal cord lesion caudal to L3. The calf bled from the blood sampling site for an extended period after venipuncture. Leukocytosis, anemia, and thrombocytopenia were observed. The leukocytes were predominantly atypical blast cells. Postmortem examination revealed petechial hemorrhages throughout the internal organs. Bone marrow was pale tan, with no red marrow seen. Atypical leukocytes were diffusely distributed throughout the body, with penetration of the spinal cord and spinal roots, particularly in the lumbar region. Atypical leukocytes stained positively for alpha-naphthyl acetate esterase and chloracetate esterase, and stained with Sudan black B. Atypical leukocytes expressed class-1 and class-2 major histocompatability antigens, but did not express specific T-, B-, or null-cell surface antigens. The final diagnosis was myelomonocytic leukemia. Differential diagnosis of leukemia in calves should include myelogenous leukemia, and requires use of various techniques to make a definitive diagnosis.
在一头患有截瘫的2月龄杂交小牛中，神经学评估结果提示脊髓损伤位于L3尾侧。该小牛在静脉穿刺后，采血部位长时间出血。观察到白细胞增多、贫血和血小板减少。白细胞主要为非典型原始细胞。尸检显示全身各内脏器官有瘀点性出血。骨髓呈淡黄褐色，未见红骨髓。非典型白细胞弥漫分布于全身，侵入脊髓和脊神经根，尤其是在腰部区域。非典型白细胞对α-萘乙酸酯酶和氯乙酸酯酶呈阳性染色，并用苏丹黑B染色。非典型白细胞表达1类和2类主要组织相容性抗原，但不表达特异性T细胞、B细胞或裸细胞表面抗原。最终诊断为骨髓单核细胞白血病。小牛白血病的鉴别诊断应包括髓细胞性白血病，且需要使用各种技术来做出明确诊断。
