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锌,革兰氏阳性菌中腺苷酸激酶的一种结构成分。

Zinc, a structural component of adenylate kinases from gram-positive bacteria.

作者信息

Gilles A M, Glaser P, Perrier V, Meier A, Longin R, Sebald M, Maignan L, Pistotnik E, Bârzu O

机构信息

Unité de Biochimie des Régulations Cellulaires, Institut Pasteur, Paris, France.

出版信息

J Bacteriol. 1994 Jan;176(2):520-3. doi: 10.1128/jb.176.2.520-523.1994.

Abstract

The recent finding that Bacillus stearothermophilus adenylate kinase contains a zinc atom coordinated to four cysteines prompted us to investigate the metal-binding properties of the enzyme from various bacteria. We conclude that zinc was present only in adenylate kinase from gram-positive species and that this property is correlated with the presence of three or four Cys residues in the sequence Cys-X2-Cys-X16-Cys-X2-Cys/Asp, in which X stands for different amino acid residues.

摘要

最近发现嗜热脂肪芽孢杆菌腺苷酸激酶含有一个与四个半胱氨酸配位的锌原子,这促使我们研究来自各种细菌的该酶的金属结合特性。我们得出结论,锌仅存在于革兰氏阳性菌的腺苷酸激酶中,并且这种特性与序列Cys-X2-Cys-X16-Cys-X2-Cys/Asp中三个或四个半胱氨酸残基的存在相关,其中X代表不同的氨基酸残基。

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