Juriloff D M
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
J Craniofac Genet Dev Biol. 1993 Oct-Dec;13(4):223-9.
An exclusion map for the major gene that causes nonsyndromic cleft lip with or without cleft palate, CL(P), in the A strain family of mice is presented. Because of linkage homology between mice and humans, this map should be of value to projects intended to map major human gene loci for CL(P). In both species, the genetic complexity of the etiology of CL(P) necessitates unusual and candidate locus approaches. More than 40% of the mouse genome has been swept. Some candidate regions include mouse chromosomes 12, 18, and 19, and candidate loci on other chromosomes should include Rara, Tgfa, Bmp2b1, and Igf-2.
本文展示了A品系小鼠家族中导致非综合征性唇裂伴或不伴腭裂（CL(P)）的主要基因的排除图谱。由于小鼠和人类之间存在连锁同源性，该图谱对于旨在绘制CL(P)主要人类基因座的项目应具有价值。在这两个物种中，CL(P)病因的遗传复杂性需要采用特殊的候选基因座方法。已扫描了超过40%的小鼠基因组。一些候选区域包括小鼠12号、18号和19号染色体，其他染色体上的候选基因座应包括Rara、Tgfa、Bmp2b1和Igf-2。
