携带免疫细胞瘤大鼠多胺排泄的昼夜节律。
Circadian rhythms in polyamine excretion by rats bearing an immunocytoma.
作者信息
Halberg F, Gehrke C W, Zinneman H H, Kuo K, Nelson W L, Dubey D P, Cadotte L M, Haus E, Scheving L E, Good R A, Rosenberg A, Soong L, Bazin H, Abdel-Monem M M
出版信息
Chronobiologia. 1976 Oct-Dec;3(4):309-22.
Large-amplitude circadian rhythms were observed in the urinary excretion of polyamines by rats bearing an immunocytoma. Control animals excreted polyamines at a lower rate but also with marked circadian variation. In confirmation of earlier observations, light-chain excretion by the tumor-bearing rats also exhibited a circadian rhythm, superimposed on an increasing trend. The potential of these rhythms as markers for the chronotherapy of cancer is noted.
在患有免疫细胞瘤的大鼠中观察到多胺的尿排泄存在大幅度的昼夜节律。对照动物排泄多胺的速率较低，但也有明显的昼夜变化。正如早期观察结果所证实的那样，荷瘤大鼠的轻链排泄也呈现出昼夜节律，且叠加在上升趋势之上。文中指出了这些节律作为癌症时辰疗法标志物的潜力。
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