Halberg F, Gehrke C W, Kuo K, Nelson W L, Sothern R B, Cadotte L M, Haus E, Scheving L E
Chronobiologia. 1978 Jul-Sep;5(3):263-76.
Under the conditions of disynchronization by the manipulation of both the alternation of light and darkness and the availability and unavailability of food, circadian rhythms characterize the excretion of several amino acids by inbred LOU rats bearing an immunocytoma. Large amplitude rhythms can be demonstrated for urinary beta-aminoisobutyric acid, beta-alanine, phenylalanine and tyrosine. Under the same conditions of disynchronization, control animals excrete the same compounds also with a marked circadian variation but at an invariably lower average rate. These excretory rhythms, along with those demonstrated earlier for polyamines and light-chains, are of interest as potential markers for the chronotherapy of cancer.
在通过改变光照和黑暗交替以及食物供应与不供应来实现不同步的条件下，昼夜节律表现为患有免疫细胞瘤的近交系LOU大鼠几种氨基酸的排泄特征。尿中的β-氨基异丁酸、β-丙氨酸、苯丙氨酸和酪氨酸可呈现大幅度的节律。在相同的不同步条件下，对照动物排泄相同的化合物时也有明显的昼夜变化，但平均速率始终较低。这些排泄节律，连同先前证明的多胺和轻链的节律，作为癌症时间疗法的潜在标志物具有重要意义。
