Flocco M M, Mowbray S L
Department of Molecular Biology, Swedish Agricultural University, Uppsala Biomedical Center.
J Mol Biol. 1994 Jan 14;235(2):709-17. doi: 10.1006/jmbi.1994.1022.
A parallel stacking arrangement of the guanidinium groups of arginines directly over the center of the rings of aromatic side-chains is observed much more frequently in proteins than would be expected by chance. This type of interaction, which is often found in locations critical to the function, apparently serves to orient the arginine side-chain without interfering with its ability to form hydrogen bonds elsewhere. It is distinct from the interactions which involve the side-chains of asparagine or glutamine, which do frequently assume a nearly planar relationship to the ring, but at a position at or beyond the ring edge.
在蛋白质中，精氨酸的胍基直接堆叠在芳香族侧链环的中心上方的平行排列方式比随机预期的更为常见。这种相互作用类型经常出现在对功能至关重要的位置，显然有助于精氨酸侧链定向，而不会干扰其在其他地方形成氢键的能力。它与涉及天冬酰胺或谷氨酰胺侧链的相互作用不同，后者确实经常与环呈现近乎平面的关系，但处于环边缘或更远处的位置。
