艾滋病病毒HIV-1的起源。
The origin of HIV-1, the AIDS virus.
作者信息
Siefkes D
出版信息
Med Hypotheses. 1993 Oct;41(4):289-99. doi: 10.1016/0306-9877(93)90069-3.
Abstract
This article proposes a series of experiments to determine if cows and sheep could be used as animal models for HIV-1, the AIDS virus. To justify this effort, a substantial case is presented that HIV-1 is a natural recombinant of Bovine Leukemia Virus (BLV) and Visna Virus. This natural recombinant may have been inadvertently transferred to humans through the Intensified Smallpox Eradication Program conducted in sub-Saharan Africa in the late 1960s and most of the 1970s.
摘要
本文提出了一系列实验，以确定牛和羊是否可作为艾滋病病毒HIV-1的动物模型。为了证明这一研究的合理性，文中提出了一个重要观点，即HIV-1是牛白血病病毒（BLV）和维斯纳病毒的天然重组体。这种天然重组体可能是在20世纪60年代末和70年代大部分时间于撒哈拉以南非洲开展的强化天花根除计划期间无意间传播给人类的。
相似文献
1
The origin of HIV-1, the AIDS virus.艾滋病病毒HIV-1的起源。
Med Hypotheses. 1993 Oct;41(4):289-99. doi: 10.1016/0306-9877(93)90069-3.
2
Maedi-visna virus and its relationship to human immunodeficiency virus.梅迪-维斯纳病毒及其与人类免疫缺陷病毒的关系。
AIDS Rev. 2005 Oct-Dec;7(4):233-45.
3
Human and ovine lentiviral infections compared.人类和绵羊慢病毒感染的比较。
Comp Immunol Microbiol Infect Dis. 1991;14(4):277-87. doi: 10.1016/0147-9571(91)90133-x.
4
[Visna and AIDS--various comparative aspects].[维斯纳病与艾滋病——各比较方面]
Nord Med. 1991;106(4):112-5.
5
Vaccinia and other viruses with available vaccines show marked homology with the HIV-1 envelope glycoprotein: the prospect of using existing vaccines to stem the AIDS pandemic.天花和其他有可用疫苗的病毒与 HIV-1 包膜糖蛋白具有显著的同源性：利用现有疫苗遏制艾滋病大流行的前景。
Immunopharmacol Immunotoxicol. 2012 Apr;34(2):222-31. doi: 10.3109/08923973.2011.596542. Epub 2011 Aug 19.
6
Recommendations for using smallpox vaccine in a pre-event vaccination program. Supplemental recommendations of the Advisory Committee on Immunization Practices (ACIP) and the Healthcare Infection Control Practices Advisory Committee (HICPAC).在事件前疫苗接种计划中使用天花疫苗的建议。免疫实践咨询委员会（ACIP）和医疗保健感染控制实践咨询委员会（HICPAC）的补充建议。
MMWR Recomm Rep. 2003 Apr 4;52(RR-7):1-16.
7
Vaccines for smallpox.天花疫苗。
Lancet. 1999 Jul 31;354(9176):422. doi: 10.1016/s0140-6736(99)00134-8.
8
Separate worlds set to collide: smallpox, vaccinia virus vaccination, and human immunodeficiency virus and acquired immunodeficiency syndrome.即将碰撞的不同世界：天花、牛痘病毒疫苗接种与人类免疫缺陷病毒及获得性免疫缺陷综合征
Clin Infect Dis. 2003 Aug 1;37(3):426-32. doi: 10.1086/375823. Epub 2003 Jul 22.
9
The origin of lentivirus research: Maedi-visna virus.慢病毒研究的起源：梅迪-维斯纳病毒。
Curr HIV Res. 2013 Jan;11(1):2-9.
10
Modeling a safer smallpox vaccination regimen, for human immunodeficiency virus type 1-infected patients, in immunocompromised macaques.在免疫功能低下的猕猴中为感染1型人类免疫缺陷病毒的患者建立更安全的天花疫苗接种方案。
J Infect Dis. 2003 Oct 15;188(8):1181-91. doi: 10.1086/378518. Epub 2003 Oct 10.
本文引用的文献
1
Visna, a demyelinating transmissible disease of sheep.维斯纳病，一种绵羊的脱髓鞘性传染病。
J Neuropathol Exp Neurol. 1957 Jul;16(3):389-403. doi: 10.1097/00005072-195707000-00010.
2
Multiple opportunistic infection due to AIDS in a previously healthy black woman from Zaire.一名来自扎伊尔的既往健康的黑人女性因艾滋病引发多种机会性感染。
N Engl J Med. 1983 Mar 31;308(13):775. doi: 10.1056/NEJM198303313081310.
3
Opportunistic infections and Kaposi's sarcoma among Haitians in the United States.美国海地人群中的机会性感染和卡波西肉瘤
MMWR Morb Mortal Wkly Rep. 1982 Jul 9;31(26):353-4, 360-1.
4
AIDS in 1968.1968年的艾滋病。 （此译文与现实不符，现实中艾滋病首次被正式报道是在1981年，原英文表述也不符合正常逻辑，可能是表述有误，但按要求进行了翻译）
JAMA. 1984 May 25;251(20):2657. doi: 10.1001/jama.1984.03340440017005.
5
General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes.表达外源基因的感染性痘苗病毒重组体的生产和选择通用方法。
J Virol. 1984 Mar;49(3):857-64. doi: 10.1128/JVI.49.3.857-864.1984.
6
Construction of live vaccines using genetically engineered poxviruses: biological activity of vaccinia virus recombinants expressing the hepatitis B virus surface antigen and the herpes simplex virus glycoprotein D.利用基因工程痘病毒构建活疫苗：表达乙型肝炎病毒表面抗原和单纯疱疹病毒糖蛋白D的痘苗病毒重组体的生物学活性
Proc Natl Acad Sci U S A. 1984 Jan;81(1):193-7. doi: 10.1073/pnas.81.1.193.
7
Molecular cloning of unintegrated visna viral DNA and characterization of frequent deletions in the 3' terminus.
Gene. 1983 Aug;23(2):137-48. doi: 10.1016/0378-1119(83)90045-8.
8
Construction of live vaccines by using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin.利用基因工程痘病毒构建活疫苗：表达流感病毒血凝素的重组痘苗病毒的生物学活性
Proc Natl Acad Sci U S A. 1983 Sep;80(17):5364-8. doi: 10.1073/pnas.80.17.5364.
9
Experiments with cloned complete tumor-derived bovine leukemia virus information prove that the virus is totally exogenous to its target animal species.对克隆的完整肿瘤源性牛白血病病毒信息进行的实验证明，该病毒对于其目标动物物种而言完全是外源性的。
J Virol. 1981 Nov;40(2):605-9. doi: 10.1128/JVI.40.2.605-609.1981.
10
A physical map of the linear unintegrated DNA of Visna virus.
Virology. 1981 Aug;113(1):412-5. doi: 10.1016/0042-6822(81)90169-0.
Zotero 插件