Niemierko A, Goitein M
Med Phys. 1993 Sep-Oct;20(5):1377-80; author reply 1381-5. doi: 10.1118/1.597103.
We believe that, for the purpose of evaluation and optimization of treatment plans, quasirandom sampling is superior to grid sampling and should be the method of choice. We believe it to be on average more efficient than grid sampling (i.e., more accurate for any given number of dose estimates) and, even more importantly, more reliable in that it is subject to less variability due to shape and orientation of the particular VOI--as demonstrated in Fig. 2. As a rule of thumb we recommend using about 400 quasirandom samples per volume of interest. For many situations this number is a conservative estimate; for a few situations more samples might be necessary. Optimal sampling for the purpose of calculation and presentation of the dose distribution is a different story which we have addressed elsewhere.
我们认为，为了评估和优化治疗方案，准随机抽样优于网格抽样，应作为首选方法。我们认为它平均比网格抽样更有效（即对于任何给定数量的剂量估计更准确），更重要的是，它更可靠，因为由于特定感兴趣体积（VOI）的形状和方向，其变异性更小——如图2所示。根据经验，我们建议每单位感兴趣体积使用约400个准随机样本。在许多情况下，这个数字是保守估计；在少数情况下，可能需要更多样本。出于计算和呈现剂量分布目的的最佳抽样则是另一回事，我们已在其他地方讨论过。
