Ardizzi A, Guzzaloni G, Grugni G, Moro D, Calò G, Mazzilli G, Tonelli E, Morabito F
Divisione di Auxologia, Centro Auxologico Italiano di Piancavallo, Novara.
Minerva Endocrinol. 1993 Jun;18(2):83-5.
It has been demonstrated that the direct and/or indirect stimulation of hematopoiesis is one of the effects of the growth hormone (GH) in vitro. In order to study the effect of GH on erythropoiesis in vivo, the variation of hemochrome in a group of 8 subjects with GH deficiency (GHD) were monitored during a substitutive therapy with biosynthetic GH (rhGH) at dose of 0.4 U/kg/week. Hemoglobin (Hb), hematocrit (Ht), mean corpuscular volume (MCV), number of red blood cells (RBC) were analysed in all subjects at the beginning and after 9 months of treatment. The effectiveness of therapy was demonstrated by statistically significant variations in height, height SDS, growth velocity, serum levels of IGF-I. After 9 months of rhGH therapy, a significant increase was observed in all values considered with exception of MCV. In conclusion Gh would appear to stimulate erythropoiesis, directly or indirectly, and these results would appear to indicate an in vivo confirmation.
已经证明，造血的直接和/或间接刺激是生长激素（GH）在体外的作用之一。为了研究GH对体内红细胞生成的影响，在一组8名生长激素缺乏症（GHD）患者接受每周0.4 U/kg的生物合成GH（rhGH）替代治疗期间，监测了血色素的变化。在治疗开始时和治疗9个月后，对所有受试者的血红蛋白（Hb）、血细胞比容（Ht）、平均红细胞体积（MCV）、红细胞数量（RBC）进行了分析。身高、身高标准差分值（SDS）、生长速度、血清IGF-I水平的统计学显著变化证明了治疗的有效性。rhGH治疗9个月后，除MCV外，所有考虑的值均显著增加。总之，GH似乎直接或间接刺激红细胞生成，这些结果似乎表明在体内得到了证实。
