Areekul S, Kirdudom P, Chaovanapricha K
Southeast Asian J Trop Med Public Health. 1976 Dec;7(4):551-8.
Djenkolic acid was extracted from djenkol beans with 70% ethanol and water and was quantitatively determined by paper chromatography. Djenkol beans contained 0.3-1.3 gm% djenkolic acid and about 93% of this acid occurred in the free state. The toxicity of djenkol beans was studied in 5 rhesus monkeys, 9 albino rats and 22 mice fed with 70% ethanol extracts. The total urinary output decreased. There was an increase in specific gravity of the urine during the period of feeding monkeys with djenkol beans. Urinary samples of the experimental animals were turbid and contained some red cells, white cells, epithelial cells, albumin and amorphous particles. One of 22 mice excreted sharp needle-shaped crystals in the urine on day 3 after feeding. Histological examination of kidneys of rats and mice showed mild to severe acute tubular necrosis with some glomerular cell necrosis.
从豆科植物阿勃勒豆中用70%乙醇和水提取了弓果藤酸，并通过纸色谱法进行定量测定。阿勃勒豆含有0.3 - 1.3克%的弓果藤酸，其中约93%的这种酸以游离状态存在。对5只恒河猴、9只白化大鼠和22只小鼠喂食70%乙醇提取物，研究了阿勃勒豆的毒性。总尿量减少。在给猴子喂食阿勃勒豆期间，尿液比重增加。实验动物的尿液样本浑浊，含有一些红细胞、白细胞、上皮细胞、白蛋白和无定形颗粒。22只小鼠中有1只在喂食后第3天尿液中排出尖锐的针状晶体。对大鼠和小鼠肾脏的组织学检查显示有轻度至重度的急性肾小管坏死以及一些肾小球细胞坏死。
