Johnson D N, Vocci F J
Medications Development Division, National Institute on Drug Abuse, Rockville, MD 20857.
NIDA Res Monogr. 1993;135:57-70.
NIDA's MDD is faced with the formidable task of identifying, characterizing, and developing new chemical entities to combat substance abuse. The primary challenge is to find one or more medications that will be useful in treating cocaine addiction, withdrawal, and abstinence. In addition, a treatment for cocaine overdose is in progress. Methodological approaches include testing compounds that alter endogenous neurotransmitters and compounds that suppress conditioned cues and stimuli. Compounds that appear efficacious in these tasks and that have a satisfactory safety profile will be studied in humans.
美国国家药物滥用研究所的药物开发部门面临着识别、表征和开发新化学实体以对抗药物滥用这一艰巨任务。主要挑战在于找到一种或多种对治疗可卡因成瘾、戒断和禁欲有用的药物。此外，针对可卡因过量的治疗正在进行中。方法学途径包括测试改变内源性神经递质的化合物以及抑制条件性线索和刺激的化合物。在这些任务中显示出有效且具有令人满意安全性的化合物将在人体中进行研究。
