溴隐亭-去甲丙咪嗪方案治疗可卡因成瘾

Bromocriptine-desipramine protocol in treatment of cocaine addiction.

作者信息

Giannini A J, Billett W

机构信息

Northeastern Ohio Universities, College of Medicine, Youngstown.

出版信息

J Clin Pharmacol. 1987 Aug;27(8):549-54. doi: 10.1002/j.1552-4604.1987.tb03065.x.

DOI:10.1002/j.1552-4604.1987.tb03065.x

PMID:3308977

Abstract

Thirty-six male cocaine abusers, in withdrawal, were studied for 99 days in a double-blind design. Treatment with bromocriptine was significantly more effective than placebo in alleviating withdrawal symptoms. Adding desipramine to the bromocriptine regimen was significantly more effective than either placebo or bromocriptine alone. The authors hypothesize that these results support a model of dopamine depletion and receptor supersensitivity in cocaine withdrawal.

摘要

36名正在戒毒的男性可卡因滥用者，采用双盲设计进行了99天的研究。在缓解戒断症状方面，溴隐亭治疗比安慰剂显著更有效。在溴隐亭治疗方案中加用去甲丙咪嗪比单独使用安慰剂或溴隐亭显著更有效。作者推测，这些结果支持可卡因戒断中多巴胺耗竭和受体超敏反应的模型。