Phillips A O, Jones H W, Hambley H, Hillis A N, Hendry B M
Renal Unit, King's College Hospital, London, UK.
Nephron. 1993;65(3):350-3. doi: 10.1159/000187511.
It has been suggested that a high prevalence of anticardiolipin antibody and lupus anticoagulant in haemodialysis patients may be a feature of dialysis membrane bioincompatibility. Previously published reports have given a prevalence of approximately 30% for IgG-anticardiolipin and 22-30% for the lupus anticoagulant in a population of haemodialysis patients, with a prevalence of 48% for IgG-anticardiolipin in a subgroup of patients dialysed with cuprophane membranes. The aim of this study was to analyse the prevalence of IgG- and IgM-anticardiolipin antibodies, and also the lupus anticoagulant in a population of haemodialysis patients dialysed exclusively with cuprophane membranes. Forty-two patients on hospital-based haemodialysis were studied. Two patients (4.8%) had IgG-anticardiolipin, and 7 (16.7%) had IgM-anticardiolipin. No patients were positive for both IgG- and IgM-anticardiolipin. All positive results were of 'low' or 'medium' positive titres. In the patients with positive results for anticardiolipin there were no documented episodes of thrombotic events. In the group studied there were no patients positive for the lupus anticoagulant. We conclude that the presence of anticardiolipin antibodies or lupus anticoagulant is rare in this population of haemodialysis patients and they are not a feature of membrane bioincompatibility.
有观点认为，血液透析患者中抗心磷脂抗体和狼疮抗凝物的高流行率可能是透析膜生物不相容性的一个特征。先前发表的报告显示，在血液透析患者群体中，IgG抗心磷脂抗体的流行率约为30%，狼疮抗凝物的流行率为22%-30%，在用铜仿膜透析的患者亚组中，IgG抗心磷脂抗体的流行率为48%。本研究的目的是分析仅用铜仿膜透析的血液透析患者群体中IgG和IgM抗心磷脂抗体以及狼疮抗凝物的流行率。对42例住院血液透析患者进行了研究。2例患者（4.8%）有IgG抗心磷脂抗体，7例（16.7%）有IgM抗心磷脂抗体。没有患者同时IgG和IgM抗心磷脂抗体均呈阳性。所有阳性结果均为“低”或“中”阳性滴度。在心磷脂抗体呈阳性的患者中，没有血栓形成事件的记录。在所研究的组中，没有患者狼疮抗凝物呈阳性。我们得出结论，在这一血液透析患者群体中，抗心磷脂抗体或狼疮抗凝物的存在很少见，它们不是膜生物不相容性的特征。
