Gurbanov I A, D'yachuk G I, Maksimuk V F
Department of Pharmacology, Sanitary-Hygiene Medical Institute, Saint Petersburg.
Neurosci Behav Physiol. 1993 Nov-Dec;23(6):580-5. doi: 10.1007/BF01153688.
The features of the effect of some calcium antagonists on local brain blood flow in the sensorimotor, auditory, and visual regions of the cerebral cortex of rabbits have been investigated in chronic experiments on rabbits using the hydrogen clearance technique, and the hydrational state of the tissue was investigated by means of impedometry. It was established that during the intravenous administration of various calcium antagonists there are individual features in the effects on particular functional zones of the cerebral cortex of rabbits. The data obtained permitted the identification of regions of mainly increased local brain blood flow during the use of the calcium antagonists we were investigating. The results of three-frequency impedometry permit a judgment regarding the changes in the degree of hydration of brain tissue during the use of calcium antagonists.
在兔的慢性实验中，采用氢清除技术研究了某些钙拮抗剂对兔大脑皮质感觉运动区、听觉区和视觉区局部脑血流的影响特征，并通过阻抗测定法研究了组织的水化状态。结果表明，在静脉注射各种钙拮抗剂时，对兔大脑皮质特定功能区的影响存在个体差异。所获得的数据有助于确定在使用我们所研究的钙拮抗剂期间局部脑血流主要增加的区域。三频阻抗测定结果有助于判断在使用钙拮抗剂期间脑组织水化程度的变化。
