Lyden P D, Zivin J A, Kochhar A, Mazzarella V
Neurology Service, Veterans Administration Medical Center, La Jolla, California.
Stroke. 1988 Aug;19(8):1020-6. doi: 10.1161/01.str.19.8.1020.
To determine the efficacy of calcium channel blockers in preserving neurologic function after central nervous system ischemia, we studied three such agents in two animal models. We treated rabbits after inducing ischemia in the brain with intra-arterial microspheres and in the spinal cord using a removable aortic occluding device. We found no benefit, in terms of neurologic functional outcome, from lidoflazine, nimodipine, or nicardipine. All three agents elevated regional blood flow in the spinal cord. We conclude that calcium antagonists are not likely to prove beneficial if used alone in the treatment of focal central nervous system ischemia.
为了确定钙通道阻滞剂在中枢神经系统缺血后保护神经功能的疗效，我们在两种动物模型中研究了三种此类药物。我们使用动脉内微球诱导兔脑缺血，并使用可移除的主动脉阻断装置诱导兔脊髓缺血，然后对其进行治疗。就神经功能结果而言，我们发现利多氟嗪、尼莫地平和尼卡地平均无益处。这三种药物均可提高脊髓局部血流量。我们得出结论，钙拮抗剂单独用于治疗局灶性中枢神经系统缺血不太可能证明有益。
