Kaptsova T I, Alekseeva A K, Gordienko N M, Rozina E E, Ermakova M N
Vopr Virusol. 1976 Nov-Dec(6):674-85.
For some years the Moscow Research Institute of Virus Preparations carried out studies concerned with the elaboration of conditions for production and control of mumps vaccine from the Leningrad-3 (L-3) strain under experimental production conditions. Twenty nine batches of the vaccine were prepared, tested and studied in extensive field trials. The paper presents the optimal conditions for the preparation of the live mumps vaccine from the L-3 strain in Japanese quail embryo cell cultures. In monkey experiments the L-3 strain was shown to have no neurovirulence. The system of biological control for the mumps vaccine permits to release the preparation meeting the current requirements for safety of live tissue culture parenteral vaccines. The data on the stability of the mumps vaccine from the L-3 strain are presented.
多年来，莫斯科病毒制剂研究所一直在开展相关研究，即在实验生产条件下，研究制定生产和控制来自列宁格勒-3（L-3）株的腮腺炎疫苗的条件。制备了29批该疫苗，并在广泛的现场试验中进行了测试和研究。本文介绍了在日本鹌鹑胚胎细胞培养物中从L-3株制备活腮腺炎疫苗的最佳条件。在猴子实验中，L-3株显示没有神经毒性。腮腺炎疫苗的生物控制体系能够放行符合现行活组织培养肠胃外疫苗安全性要求的制剂。文中还给出了来自L-3株的腮腺炎疫苗稳定性的数据。
