Kofler M, Kronenberg M F, Rifici C, Saltuari L, Bauer G
Department of Neurology, University of Innsbruck, Austria.
Neurology. 1994 Jan;44(1):25-7. doi: 10.1212/wnl.44.1.25.
We report the clinical and EEG findings in three patients presenting with seizures associated with intrathecal baclofen application for treatment of spasticity. All patients had a history of traumatic brain injury, while one patient also suffered a spinal cord injury. Two patients experienced their first seizure following intrathecal baclofen test bolus injection. Another patient had convulsions on two occasions: following postoperative baclofen dose adjustment, and after sleep deprivation. Structural brain disease seems prerequisite for baclofen to exert epileptogenic activity, since seizures have not occurred in patients receiving intrathecal baclofen for spasticity of solely spinal origin. Antiepileptic medication permitted the continuation of intrathecal baclofen treatment in the three patients.
我们报告了3例鞘内注射巴氯芬治疗痉挛相关癫痫发作患者的临床及脑电图检查结果。所有患者均有创伤性脑损伤病史，其中1例还伴有脊髓损伤。2例患者在鞘内注射巴氯芬试验剂量后首次发作癫痫。另1例患者有两次抽搐发作：一次是在术后巴氯芬剂量调整后，另一次是在睡眠剥夺后。结构性脑部疾病似乎是巴氯芬发挥致痫作用的先决条件，因为接受鞘内注射巴氯芬治疗单纯脊髓源性痉挛的患者未发生癫痫发作。抗癫痫药物使3例患者得以继续鞘内注射巴氯芬治疗。
