Salemi G, Savettieri G, Rocca W A, Meneghini F, Saporito V, Morgante L, Reggio A, Grigoletto F, Di Perri R
Department of Neurology, University of Palermo, Italy.
Neurology. 1994 Jan;44(1):61-4. doi: 10.1212/wnl.44.1.61.
As part of a door-to-door neuroepidemiologic survey, we investigated the frequency and distribution of essential tremor (ET) in a Sicilian municipality. During phase 1, we administered a screening instrument for tremor to 7,653 persons residing in Terrasini (Palermo province). During phase 2, neurologists evaluated those subjects who had screened positive. The diagnoses, based on specified clinical criteria, were reviewed to increase reliability across neurologists. We found 31 subjects affected by ET (17 men, 14 women); 11 patients (35.5%) reported a familial aggregation. The prevalence of ET as of November 1, 1987, was 405.1 per 100,000 for the total population, and 1,074.9 per 100,000 for those 40 years old or older. The prevalence increased with advancing age for both sexes and was slightly but consistently higher in men. Comparison with other studies suggests striking geographic variation, which may reflect genetic differences.
作为一项挨家挨户进行的神经流行病学调查的一部分，我们在西西里岛的一个市镇调查了特发性震颤（ET）的发病率和分布情况。在第一阶段，我们对居住在特拉西尼（巴勒莫省）的7653人进行了震颤筛查。在第二阶段，神经科医生对筛查呈阳性的受试者进行了评估。根据特定的临床标准进行诊断复查，以提高不同神经科医生诊断的可靠性。我们发现31名受试者患有ET（17名男性，14名女性）；11名患者（35.5%）报告有家族聚集现象。截至1987年11月1日，ET在总人口中的患病率为每10万人405.1例，在40岁及以上人群中为每10万人1074.9例。男女患病率均随年龄增长而增加，男性患病率略高但较为稳定。与其他研究的比较表明存在显著的地理差异，这可能反映了基因差异。
