阴道内使用米索前列醇与地诺前列酮作为宫颈成熟和引产药物的比较。
Intravaginal misoprostol versus dinoprostone as cervical ripening and labor-inducing agents.
作者信息
Fletcher H, Mitchell S, Frederick J, Simeon D, Brown D
机构信息
Department of Obstetrics and Gynaecology, University of the West Indies, Mona, Kingston, Jamaica.
出版信息
Obstet Gynecol. 1994 Feb;83(2):244-7.
OBJECTIVE
To compare dinoprostone (prostaglandin E2) and misoprostol (prostaglandin E1) for ripening the cervix and inducing labor at term.
METHODS
Sixty-three women were randomized to receive 100 micrograms misoprostol or 3 mg dinoprostone, both as intravaginal tablets.
RESULTS
There was no statistical difference between the groups for pre-induction status. The mean Bishop scores before drug insertion were almost identical. Twelve hours after insertion, the mean change in the Bishop score was significantly higher in those receiving misoprostol (5.0 versus 3.3) (P = .008). However, there were no significant differences in induction-to-delivery interval, spontaneous labor rates, type of delivery, fetal outcome, or maternal complications.
CONCLUSION
Misoprostol is as effective as dinoprostone for inducing labor at term.
目的
比较地诺前列酮（前列腺素E2）和米索前列醇（前列腺素E1）足月促宫颈成熟及引产的效果。
方法
63名妇女被随机分为两组，分别接受100微克米索前列醇或3毫克地诺前列酮，均采用阴道片剂给药。
结果
两组引产术前情况无统计学差异。用药前的平均 Bishop 评分几乎相同。用药12小时后，接受米索前列醇组的 Bishop 评分平均变化显著高于地诺前列酮组（5.0对3.3）（P = .008）。然而，两组在引产至分娩间隔、自然分娩率、分娩方式、胎儿结局或母体并发症方面无显著差异。
结论
米索前列醇在足月引产方面与地诺前列酮效果相当。
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