Buser D, Mora G, Arias F
Department of Obstetrics and Gynecology, St. John's Mercy Medical Center, St. Louis, Missouri.
Obstet Gynecol. 1997 Apr;89(4):581-5. doi: 10.1016/S0029-7844(97)00015-X.
To compare the efficacy and safety of two prostaglandin derivatives, misoprostol and dinoprostone, for ripening the cervix and inducing labor in women with an unfavorable cervix.
One hundred fifty-five women admitted for induction of labor to St. John's Mercy Medical Center, a teaching community hospital, were randomized to one of two methods: intravaginal misoprostol, 50 microg every 4 hours up to three doses (n = 76); and intracervical dinoprostone gel, 0.5 mg every 6 hours up to three doses (n = 79).
Misoprostol was more effective than dinoprostone in causing cervical ripening (P = .01), inducing labor (P < .001), shortening the duration of labor (P < .001), and decreasing the need for oxytocin augmentation (P < .001). Nonreassuring fetal heart monitoring patterns associated with hyperstimulation were significantly more frequent (P < .001), and the incidence of cesarean deliveries because of this indication was significantly higher (P = .002) in patients receiving misoprostol.
Misoprostol is an effective agent for cervical ripening and labor induction, but it causes an increase in cesarean deliveries associated with uterine hyperstimulation.
比较两种前列腺素衍生物米索前列醇和地诺前列酮在宫颈条件不佳的女性中促宫颈成熟及引产的疗效和安全性。
155名入住教学社区医院圣约翰慈善医疗中心待产的女性被随机分为两种方法之一：阴道内给予米索前列醇，每4小时50微克，最多三剂（n = 76）；宫颈内给予地诺前列酮凝胶，每6小时0.5毫克，最多三剂（n = 79）。
米索前列醇在促宫颈成熟（P = 0.01）、引产（P < 0.001）、缩短产程（P < 0.001）及减少催产素加强的需求（P < 0.001）方面比地诺前列酮更有效。与子宫收缩过强相关的胎儿心率监测异常情况在接受米索前列醇的患者中显著更频繁（P < 0.001），且因该指征行剖宫产的发生率显著更高（P = 0.002）。
米索前列醇是一种有效的促宫颈成熟及引产药物，但它会导致与子宫收缩过强相关的剖宫产增加。
