Unsal H, Yakicier C, Marçais C, Kew M, Volkmann M, Zentgraf H, Isselbacher K J, Ozturk M
Massachusetts General Hospital Cancer Center, Charlestown 02129.
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):822-6. doi: 10.1073/pnas.91.2.822.
We studied 80 hepatocellular carcinomas from three continents for p53 gene (TP53) mutations and hepatitis B virus (HBV) sequences. p53 mutations were frequent in tumors from Mozambique but not in tumors from South Africa, China, and Germany. Independent of geographic origin, most tumors were positive for HBV sequences. X gene coding sequences of HBV were detected in 78% of tumors, whereas viral sequences in the surface antigen- and core antigen-encoding regions were present in less than 45% of tumors. These observations indicate that hepatocellular carcinomas are genetically heterogeneous. Mozambican-type of hepatocellular carcinomas are characterized by a high incidence of p53 mutations related to aflatoxins. In other tumors, the rarity of p53 mutations combined with the frequent presence of viral X gene coding sequences suggests a possible interference of HBV with the wild-type p53 function.
我们研究了来自三大洲的80例肝细胞癌的p53基因（TP53）突变情况及乙型肝炎病毒（HBV）序列。p53突变在莫桑比克的肿瘤中很常见，但在南非、中国和德国的肿瘤中则不然。与地理来源无关，大多数肿瘤的HBV序列呈阳性。78%的肿瘤中检测到HBV的X基因编码序列，而表面抗原和核心抗原编码区域的病毒序列在不到45%的肿瘤中存在。这些观察结果表明肝细胞癌在基因上具有异质性。莫桑比克型肝细胞癌的特征是与黄曲霉毒素相关的p53突变发生率很高。在其他肿瘤中，p53突变的罕见性与病毒X基因编码序列的频繁存在表明HBV可能干扰野生型p53功能。
