Petty F, Fulton M, Moeller F G, Kramer G, Wilson L, Fraser K, Isbell P
Department of Veterans Affairs Medical Center, Psychiatry Service, Dallas, TX 75216.
Psychopharmacol Bull. 1993;29(2):277-81.
Plasma levels of gamma-aminobutyric acid (GABA) were measured in male alcoholics on admission to inpatient treatment and at discharge after 3 to 4 weeks of abstinence. Free plasma GABA at discharge was significantly lower in alcoholics than in control subjects and specifically identified a subset of 35 percent of the alcoholic patients with levels below the normal range. However, levels of free plasma GABA in recently detoxified alcoholics on admission were not different from those of controls and had a significant positive correlation with liver enzymes and mean corpuscular volume. These data are compatible with a GABA deficit theory of alcoholism in a subset of alcoholics.
在男性酗酒者入院接受住院治疗时以及戒酒3至4周后出院时，测量其血浆γ-氨基丁酸（GABA）水平。酗酒者出院时的游离血浆GABA水平显著低于对照组，并且明确发现35%的酗酒患者亚组水平低于正常范围。然而，近期戒酒的酗酒者入院时的游离血浆GABA水平与对照组无异，且与肝酶和平均红细胞体积呈显著正相关。这些数据与一部分酗酒者的酒精中毒GABA缺乏理论相符。
