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慢性酗酒者的血浆γ-氨基丁酸水平

Plasma GABA levels in chronic alcoholics.

作者信息

Coffman J A, Petty F

出版信息

Am J Psychiatry. 1985 Oct;142(10):1204-5. doi: 10.1176/ajp.142.10.1204.

DOI:10.1176/ajp.142.10.1204
PMID:4037136
Abstract

Ethanol intoxication has been noted to cause marked changes in brain and CSF levels of gamma-aminobutyric acid (GABA). Using plasma GABA levels to assess brain GABA activity, the authors found that 85 chronic alcoholics had significantly lower levels than control subjects.

摘要

乙醇中毒已被证实会导致大脑和脑脊液中γ-氨基丁酸(GABA)水平发生显著变化。作者通过测量血浆GABA水平来评估大脑GABA活性,发现85名慢性酒精中毒患者的血浆GABA水平显著低于对照组。

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Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly.
Neurochem Res. 2004 Dec;29(12):2311-5. doi: 10.1007/s11064-004-7041-3.
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Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice.参与小鼠急性酒精戒断遗传易感性的数量性状基因座。
J Neurosci. 1997 May 15;17(10):3946-55. doi: 10.1523/JNEUROSCI.17-10-03946.1997.
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Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol.γ-氨基丁酸能系统在酒精行为和细胞作用中的作用的分子遗传学分析
Behav Genet. 1996 May;26(3):313-23. doi: 10.1007/BF02359387.