Silva R R, Malone R P, Anderson L T, Shay J, Campbell M
Department of Psychiatry, New York University Medical Center, NY 10016.
Psychopharmacol Bull. 1993;29(2):287-91.
The long-term effects of haloperidol on weight were assessed in 30 children, 25 males and 5 females, diagnosed with autistic disorder whose ages ranged from 3.08 to 8.42 years. They received haloperidol (0.25-3.50 mg/day; mean 1.26 +/- 0.84) for 6 months followed by a 4-week drug withdrawal period. Weights obtained on the last day of the 6-month haloperidol period were compared to weights obtained following drug withdrawal. There was no significant difference between the mean weights obtained on the last day of haloperidol administration (24.799 +/- 9.741 kg) compared to the mean weights at the end of the fourth week of the placebo period (24.644 +/- 9.833 kg). Weights increased during the first week of drug discontinuation (24.879 +/- 9.855 kg), but decreased during each following week of drug withdrawal. Weight was measured monthly during the 6-month haloperidol treatment period for 8 of the 30 subjects. In this subsample, weight gain was greater during the 1-month period lasting from the end of the 4-week drug withdrawal to the end of the first month after resuming haloperidol treatment than weight gain prior to drug withdrawal, between the fifth and sixth month of haloperidol treatment.
在30名被诊断患有自闭症谱系障碍的儿童（25名男性和5名女性）中评估了氟哌啶醇对体重的长期影响，这些儿童年龄在3.08至8.42岁之间。他们接受氟哌啶醇治疗（0.25 - 3.50毫克/天；平均1.26±0.84），为期6个月，随后是4周的停药期。将氟哌啶醇治疗6个月最后一天测得的体重与停药后测得的体重进行比较。氟哌啶醇给药最后一天测得的平均体重（24.799±9.741千克）与安慰剂期第四周结束时的平均体重（24.644±9.833千克）之间没有显著差异。停药第一周体重增加（24.879±9.855千克），但在随后的每一周停药期间体重下降。在30名受试者中的8名接受6个月氟哌啶醇治疗期间每月测量体重。在这个子样本中，从4周停药结束到恢复氟哌啶醇治疗后第一个月末的1个月期间体重增加大于氟哌啶醇治疗第五和第六个月期间停药前的体重增加。
