Perry R, Campbell M, Adams P, Lynch N, Spencer E K, Curren E L, Overall J E
J Am Acad Child Adolesc Psychiatry. 1989 Jan;28(1):87-92. doi: 10.1097/00004583-198901000-00016.
The aim of this study was to evaluate the long-term efficacy of haloperidol in autistic children and to determine whether discontinuous drug administration was as effective as continuous drug administration. Sixty children, 48 males and 12 females, ages 2.3 to 7.9 years (X 5.1) completed the study. They received haloperidol over a period of 6 months followed by a 4-week drug withdrawal/placebo period. Haloperidol remained effective, and the discontinuous treatment schedule did not diminish its efficacy. Children with prominent symptoms of irritability, angry and labile affect, and uncooperativeness were the best responders to haloperidol.
本研究的目的是评估氟哌啶醇对自闭症儿童的长期疗效，并确定间断给药是否与连续给药同样有效。60名儿童（48名男性和12名女性），年龄在2.3至7.9岁之间（平均5.1岁）完成了该研究。他们接受了为期6个月的氟哌啶醇治疗，随后是4周的停药/安慰剂期。氟哌啶醇仍然有效，间断治疗方案并未降低其疗效。具有明显易怒、情绪愤怒和不稳定以及不合作症状的儿童对氟哌啶醇反应最佳。
