用于塑料和橡胶制造的单体在人体组织中存在的证据。
Evidence for existence in human tissues of monomers for plastics and rubber manufacture.
作者信息
Wolff M S
出版信息
Environ Health Perspect. 1976 Oct;17:183-7. doi: 10.1289/ehp.7617183.
Abstract
Although exposure to many industrially important monomers is controlled by law, few of these reactive chemicals have been determined in human tissues. Analogy with other fat-soluble organic substances strongly implies that these monomers may be retained in tissue, subject to the usual physiological constraints of metabolism, solubility and volatility. The storage of DDT and PCBs is discussed, as well as tetrachloro-ethylene (PCE) and trichloroethylene (TCE), which are chemically similar to many industrially used monomers. Styrene in blood and breath and its metabolites in urine have been studied in humans. Styrene and vinyl chloride have been measured in fat tissue of polymerization workers.
摘要
尽管许多具有工业重要性的单体的接触受到法律控制，但在人体组织中确定的这类活性化学物质却很少。与其他脂溶性有机物质的类比强烈表明，这些单体可能会保留在组织中，但会受到代谢、溶解度和挥发性等常见生理限制。文中讨论了滴滴涕和多氯联苯的储存情况，以及与许多工业用单体化学性质相似的四氯乙烯（PCE）和三氯乙烯（TCE）。已对人体血液和呼出气体中的苯乙烯及其尿液中的代谢产物进行了研究。还对聚合工人脂肪组织中的苯乙烯和氯乙烯进行了测量。
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