Fustinoni S, Campo L, Cirla A M, Cirla P E, Cutugno V, Lionetti C, Martinotti I, Mossini E, Foà V
Clinica del Lavoro, Università degli Studi di Milano e Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano.
G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl):284-6.
This survey was carried out in the molding of plastics and rubbers, in the "Professional Cancer Prevention Project" sponsored by the Lombardy region with the objective of developing and implementing protocols for evaluating exposure to carcinogens through the biological monitoring. The realities of molding the thermoplastic polymer ABS, rubber, and thermosetting plastics containing formaldehyde were examined. The carcinogenic substances identified in these processes were: 1,3-butadiene, acrylonitrile and styrene in molding ABS, polycyclic aromatic hydrocarbons (PAH) in molding rubber, and formaldehyde in molding the thermosetting plastics. Only for some of these substances biological indicators are available. The limited exposure to airborne chemicals in molding ABS and the intrinsic characteristics of biological indicators available for 1-3 butadiene have determined the non applicability of biological monitoring to this situation. The absence of a biological indicator of exposure to formaldehyde has made this situation not investigable. Exposure in the rubber molding was studied in 19 subjects applying the determination not metabolized PAH in urine. The levels of these indicators were similar to those measured in other groups of subjects without occupational exposure to PAH, confirming a low airborne contamination in this workplace.
这项调查是在塑料和橡胶成型领域开展的，是伦巴第大区发起的“职业癌症预防项目”的一部分，目的是制定和实施通过生物监测评估致癌物暴露的方案。研究了热塑性聚合物ABS、橡胶以及含甲醛热固性塑料的成型实际情况。在这些工艺中识别出的致癌物质有：成型ABS时的1,3 - 丁二烯、丙烯腈和苯乙烯，成型橡胶时的多环芳烃（PAH），以及成型热固性塑料时的甲醛。只有其中一些物质有生物指标。在成型ABS过程中空气传播化学物质的暴露有限，以及1 - 3丁二烯现有生物指标的内在特性，决定了生物监测不适用于这种情况。缺乏甲醛暴露的生物指标使得这种情况无法进行调查。对19名受试者的橡胶成型暴露情况进行了研究，采用测定尿中未代谢PAH的方法。这些指标的水平与在其他未职业接触PAH的受试者组中测得的水平相似，证实了该工作场所空气中污染程度较低。
