Albornoz-Plata A
G E N. 1975 Jul-Dec;30(1-2):107-14.
A brief review of the role of gastrin on gastric secretion and its influence in the genesis of peptic ulcer is made. A report is made of the pharmacological studies of Proglumida and its antigastrin action and the interest its association with Hioscin Butil-Bromuro may represent in the antiulcer therapy. A study is made of 26 patients submitted to a general treatment for peptic ulcer this drug together with a bland diet and psychotherapy. The results were: 19 (73%) cases cured; 6 (23%) cases improved; no results in 1 (4%) case. No secondary side effects appear and the symptomatic response appears 8 days after the treatment is initiated. The dosis used is of 2 tablets before the 3 main meals. Each tablet contains 250 mg of Proglumide and 10 mg of Hioscin Butil-Bromuro. It is considered useful in the antiulcer therapy to have available a drug which can control the physiological effects of gastrin and from this point of view its action is different from that of the antiacids and anticolinergics.
本文简要回顾了胃泌素对胃酸分泌的作用及其在消化性溃疡发病机制中的影响。报告了丙谷胺及其抗胃泌素作用的药理学研究，以及其与丁溴东莨菪碱联合使用在抗溃疡治疗中的意义。对26例接受消化性溃疡综合治疗的患者进行了研究，该药物与清淡饮食及心理治疗相结合。结果显示：19例（73%）治愈；6例（23%）好转；1例（4%）无效。未出现继发副作用，治疗开始8天后出现症状性缓解。所用剂量为三餐前各服2片。每片含250毫克丙谷胺和10毫克丁溴东莨菪碱。从能控制胃泌素生理效应这一角度来看，有这样一种药物在抗溃疡治疗中是有用的，其作用不同于抗酸药和抗胆碱能药。
