Baldwin D R, Wise R, Andrews J M, Gill M, Honeybourne D
Department of Thoracic Medicine, Dudley Road Hospital, Birmingham, U.K.
Respir Med. 1993 Nov;87(8):595-601. doi: 10.1016/s0954-6111(05)80262-8.
In a comparative study, the concentrations of two fluoroquinolone antimicrobials, ciprofloxacin and lomefloxacin, were measured in serum, bronchial mucosal biopsies, epithelial lining fluid (ELF) and alveolar macrophages (AM). Thirty-four subjects received either ciprofloxacin 250 mg b.d. (17 subjects) or lomefloxacin 400 mg o.d. for 4 days prior to sampling by bronchoscopic bronchial biopsy and bronchoalveolar lavage. Both ciprofloxacin and lomefloxacin showed favourable accumulation in the sites of infection with bronchial biopsy concentrations of 1.6 and 1.7 times those of serum respectively; ELF concentrations of 2.1 and 1.9 times serum; and AM concentrations of 11.8 and 20.1 times serum respectively. The MIC90 for most of the common chest pathogens was reliably exceeded by both agents except for that of Streptococcus pneumoniae.
在一项对比研究中，对血清、支气管黏膜活检组织、上皮衬液（ELF）和肺泡巨噬细胞（AM）中两种氟喹诺酮类抗菌药物环丙沙星和洛美沙星的浓度进行了测定。34名受试者在通过支气管镜进行支气管活检和支气管肺泡灌洗采样前4天，分别接受了每日两次250mg环丙沙星治疗（17名受试者）或每日一次400mg洛美沙星治疗。环丙沙星和洛美沙星在感染部位均表现出良好的蓄积，支气管活检组织中的浓度分别是血清浓度的1.6倍和1.7倍；ELF浓度分别是血清浓度的2.1倍和1.9倍；AM浓度分别是血清浓度的11.8倍和20.1倍。除肺炎链球菌外，两种药物均能可靠地超过大多数常见肺部病原体的MIC90。
