Sánchez Nieto J M, Carrillo Alcaraz A, Martín Luengo F, Pardo Talavera J C, Ruiz Gómez J, Pujante Ródenas V
Unidad de Cuidados Intensivos, Hospital Universitario Virgen de la Arrixaca, Murcia.
Rev Clin Esp. 1993 Nov;193(7):371-7.
Pneumonias related to mechanical ventilation pose a serious diagnostic challenge and are responsible for elevated mortality. Conventional diagnostic methods are of little help. The introduction of invasive techniques such as bronchial catling via an occluded telescopic catheter (OTC) has proven to be an important advance in diagnosis and therapy. We have compared the bacteriological results obtained using OTC with those using conventional diagnostic methods such as tracheobronchial pumps (TBP) and hemocultures, and we have undertaken a bacteriological, clinical follow-up of the cases. Seventy-four patients under mechanical ventilation and suspected of pneumonia were under study. The study consisted to two consecutive phases of collecting bacteriological samples throughout the patient's evolution. A total of 121 fibrobronchoscopies were performed. The sensitivity obtained with OTC was 76%, and the specificity was 100%. The two techniques, OTC and TBP, coincided in 38% of the cases. According to the bacteriological results obtained with OTC, the antibiotic treatment was modified in 44.5% of the patients. The sensitivity of the OTC was significantly less in those patients were the last doses of antibiotic was administered within two hours of performing the procedure. The procedure of gathering secretions from the inferior respiratory tract with OTC possesses greater sensitivity and diagnostic specificity in patients with mechanical ventilation and pulmonary infiltrates and improves the diagnosis performed by other conventional and routine techniques such as TBA and hemocultures.
与机械通气相关的肺炎构成了严重的诊断挑战,且是死亡率升高的原因。传统诊断方法帮助不大。诸如通过闭塞式伸缩导管(OTC)进行支气管插管等侵入性技术的引入已被证明是诊断和治疗方面的一项重要进展。我们比较了使用OTC获得的细菌学结果与使用诸如气管支气管泵(TBP)和血培养等传统诊断方法获得的结果,并对这些病例进行了细菌学、临床随访。对74例接受机械通气且疑似肺炎的患者进行了研究。该研究包括在患者整个病程中连续两个阶段采集细菌学样本。总共进行了121次纤维支气管镜检查。OTC获得的敏感性为76%,特异性为100%。OTC和TBP这两种技术在38%的病例中结果一致。根据OTC获得的细菌学结果,44.5%的患者的抗生素治疗方案得到了调整。在那些在进行该操作前两小时内给予了最后一剂抗生素的患者中,OTC的敏感性显著降低。通过OTC从下呼吸道采集分泌物的操作在机械通气和肺部浸润患者中具有更高的敏感性和诊断特异性,并改善了通过诸如TBA和血培养等其他传统常规技术所进行的诊断。