Matthys H, Knoch M, Eltschka R
Department of Internal Medicine, University Hospital, Freiburg, FRG.
Respiration. 1993;60(6):343-50. doi: 10.1159/000196233.
A special new device for diagnostic (bronchoprovocation) and therapeutic aerosol application is described. It consists of a high quality nebulizer system combined with a 10-liter storage bag which serves as an aerosol 'conditioner' (saturated ambient temperature and pressure conditions) and as a holding chamber to increase the respirable aerosol fraction and hence pulmonary deposition (Pari Provocation Test I). It allows ten times better standardized pulmonary aerosol deposition compared with the generally used nebulizers for calculation of dose-response curves especially for asthma provocation and dilatation tests. If slow inspiratory vital capacity maneuvers are used, pulmonary deposition of about 100 mg aerosol is achieved in children and adults. This device is especially important when exact dosing (also for therapeutic reasons) is required in the expanding field of topical and systemic aerosol application to or via the lung.
本文描述了一种用于诊断性（支气管激发）和治疗性气溶胶给药的新型特殊装置。它由一个高质量的雾化器系统和一个10升的储存袋组成，该储存袋用作气溶胶“调节器”（饱和环境温度和压力条件）以及一个储存室，以增加可吸入气溶胶分数，从而提高肺部沉积率（帕里激发试验I）。与通常用于计算剂量反应曲线的雾化器相比，它能使肺部气溶胶沉积的标准化程度提高十倍，尤其适用于哮喘激发和扩张试验。如果采用慢吸气肺活量动作，儿童和成人可实现约100毫克气溶胶的肺部沉积。在肺部局部和全身气溶胶给药这一不断扩展的领域中，当需要精确给药（也是出于治疗原因）时，该装置尤为重要。
