Ishii M, Iijima H, Katsumata U, Shimizu Y, Inoue H, Sasaki H, Takishima T, Ishihara H, Kobayashi T, Ito H
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Respir Physiol. 1989 Oct;78(1):107-21. doi: 10.1016/0034-5687(89)90146-1.
We developed a device to measure inhaled aerosol deposition in the lung from the difference in particle size distribution of the aerosol during inspiration and expiration. To measure quantity and size distribution of nebulized aerosol particles directly at the subject's mouth we used a He-Ne gas laser scattering technique. To test the reliability of the instrument, we measured particle size distributions of saline aerosols generated by four kinds of nebulizer and compared the results with those from a Malvern 2600D particle sizer as a standard of comparison. Measured mass median diameters (MMDs) were almost identical by both methods. Aerosol deposition in five normal subjects showed that the deposition fraction of the particles increased the larger the particle sizes inhaled. The data suggest that the newly developed aerosol spectrometer can directly analyze aerosol particle size distribution at the mouth during tidal breathing, and that the instrument is useful for quantitative analysis of aerosol inhaled and of inhaled aerosol deposition.
我们开发了一种通过测量吸气和呼气过程中气溶胶粒径分布的差异来测定肺部吸入气溶胶沉积的装置。为了直接在受试者口腔处测量雾化气溶胶颗粒的数量和粒径分布，我们采用了氦氖气体激光散射技术。为测试该仪器的可靠性，我们测量了由四种雾化器产生的盐水气溶胶的粒径分布，并将结果与作为比较标准的马尔文2600D粒度分析仪的结果进行比较。两种方法测得的质量中值直径（MMD）几乎相同。对五名正常受试者的气溶胶沉积研究表明，吸入的颗粒粒径越大，沉积分数越高。数据表明，新开发的气溶胶光谱仪可在潮气呼吸时直接分析口腔处的气溶胶粒径分布，且该仪器对于定量分析吸入气溶胶及吸入气溶胶沉积很有用。
