Lehmann W, Benchaou M, Slosman D O, Townsend D, Ryser J E, Widmann J J, Rüfenacht D, Lacroix J S, Donath A
Clinique d'oto-rhino-laryngologie et de chirurgie cervico-faciale, Hôpital cantonal universitaire de Genève.
Schweiz Rundsch Med Prax. 1993 Dec 14;82(50):1457-61.
The distribution of specific radiolabeled biological compounds in tumor tissues can be imaged by positron emission tomography (PET). The substance used is fluorodeoxyglucose, labeled with the positron emitter fluorine-18. This substance is partly trapped in tumor cells with increased glucose metabolism. This noninvasive imaging technique allows to assess quantitatively and in three dimensions the extent of metastatic disease in ENT cancer. The case presented illustrates the important value we foresee for this new imaging modality in the presurgical staging of cervical metastatic disease of ENT tumors. Sensitivity and specificity of the PET-FDG imaging technique for the loco-regional staging of ENT cancer are, according to preliminary results of an ongoing, prospective clinical study, very high.
通过正电子发射断层扫描（PET）可以对特定放射性标记生物化合物在肿瘤组织中的分布进行成像。所使用的物质是用正电子发射体氟 - 18标记的氟脱氧葡萄糖。这种物质部分被困在葡萄糖代谢增加的肿瘤细胞中。这种非侵入性成像技术能够在三维空间中定量评估耳鼻喉癌转移疾病的范围。所展示的病例说明了我们预见到这种新的成像方式在耳鼻喉肿瘤颈部转移疾病术前分期中的重要价值。根据一项正在进行的前瞻性临床研究的初步结果，PET - FDG成像技术对耳鼻喉癌局部区域分期的敏感性和特异性非常高。
