Goodman S, Aspenberg P, Wang J S, Song Y, Doshi A, Regula D, Emmanual J, Lidgren L
Department of Orthopedics, University Hospital, Lund, Sweden.
Acta Orthop Scand. 1993 Dec;64(6):627-33. doi: 10.3109/17453679308994585.
Particles of bone cement have been shown previously to stimulate the resorption of bone. The purpose of this study was to determine whether particles of bone cement (BC) have an adverse effect on bone ingrowth. The bone harvest chamber was implanted bilaterally in the proximal tibial metaphysis of 6 mature rabbits. Both the fixed outer cylinder and the inner removable core of the chamber have a transverse 1 mm wide pore providing a continuous canal for tissue ingrowth. After an initial 6-week period for osseointegration of the outer cylinder, the contents of the inner core were harvested repeatedly at 3 weekly intervals. In the first series of rabbits, the carrier solution, 1% sodium hyaluronate (Healon) was implanted first. In subsequent implantations, Healon was mixed with small fabricated particles of BC (averaging 3.54 mm in diameter) to fill the channel of the core. The contralateral chamber was left empty and served as a control. In the second series of rabbits, implantation was carried out sequentially using the same material bilaterally. The sections from the control harvests, and those with Healon alone contained extensive trabecular bone arranged longitudinally in the canal, in a fibrovascular stroma. The sections containing BC particles were infiltrated by foamy, mononuclear and multinuclear histiocytic cells. Less trabecular bone was seen in the sections containing BC particles compared to the control sections or those containing Healon alone. Previous studies have shown that particles of bone cement stimulate bone resorption. In this study, BC particles have also been shown to diminish the formation of new bone.
先前已表明骨水泥颗粒会刺激骨吸收。本研究的目的是确定骨水泥（BC）颗粒是否对骨长入有不良影响。在6只成年兔的胫骨近端干骺端双侧植入骨采集腔。腔室的固定外筒和可移除内芯均有一个横向1毫米宽的孔隙，为组织长入提供连续通道。在外筒进行初始6周的骨整合期后，每隔3周重复采集内芯的内容物。在第一组兔子中，首先植入载体溶液1%透明质酸钠（喜辽妥）。在随后的植入中，将喜辽妥与小的人造BC颗粒（平均直径3.54毫米）混合以填充芯的通道。对侧腔室保持为空作为对照。在第二组兔子中，双侧依次使用相同材料进行植入。对照采集的切片以及仅含喜辽妥的切片在纤维血管基质中含有沿管纵向排列的大量小梁骨。含有BC颗粒的切片被泡沫状、单核和多核组织细胞浸润。与对照切片或仅含喜辽妥的切片相比，含有BC颗粒的切片中可见的小梁骨较少。先前的研究表明骨水泥颗粒会刺激骨吸收。在本研究中，BC颗粒也已被证明会减少新骨的形成。
