Goodman S, Aspenberg P
Stanford University School of Medicine, Division of Orthopaedic Surgery, CA 94305-5326.
Biomaterials. 1992;13(13):944-8. doi: 10.1016/0142-9612(92)90118-8.
The micromotion chamber for implantation in the rabbit tibia consists of two titanium components that have a 1 mm contiguous pore for bone ingrowth. The fixed, outer cylinder of the chamber contains a movable inner core that can be manually rotated. The model is unique because specific, discrete, daily periods of motion of a predetermined amplitude and frequency can be delivered to the ingrowing tissue. In the present study, we compared the histological and scintigraphic results of bone ingrowth into chambers having a congruently shaped interface that was moved 20 cycles/d with an amplitude of either 0.5 or 0.75 mm. Histological sections from both amplitude groups contained extensive new woven and trabecular bone, embedded in a fibrovascular network. However, the chambers with a larger amplitude of motion yielded less bone ingrowth than those with a smaller amplitude. These studies suggest that short, discrete periods of motion can stimulate the formation of fibrous tissue rather than bone using the parameters chosen in this model.
用于植入兔胫骨的微动腔由两个钛部件组成，它们有一个1毫米的连续孔隙以供骨长入。腔的固定外圆柱体包含一个可手动旋转的活动内芯。该模型的独特之处在于，可以将特定的、离散的、具有预定幅度和频率的每日运动周期传递到正在生长的组织中。在本研究中，我们比较了骨长入界面形状一致的腔室的组织学和闪烁显像结果，这些腔室以每天20个周期的频率移动，幅度分别为0.5毫米或0.75毫米。两个幅度组的组织学切片都含有大量新的编织骨和小梁骨，嵌入在纤维血管网络中。然而，运动幅度较大的腔室的骨长入比幅度较小的腔室少。这些研究表明，使用该模型中选择的参数，短时间、离散的运动周期可刺激纤维组织而非骨的形成。
