González Carmona V M, García R, Camacho P, Jerjes Sánchez C, Arévila N, Hernández H, Nieto Castillo S
Hospital de Cardiología, Centro Médico Nacional Siglo XXI, IMSS, México, D.F.
Arch Inst Cardiol Mex. 1993 Sep-Oct;63(5):435-9.
A comparison of ANP and RAA. In 6 healthy subjects < 50 y, 5 healthy subjects > 50 y, 44 patients with essential hypertension < 50 y, and 41 patients with essential hypertension > 50 y, was performed. ANP values in healthy subjects < 50 y, were means = 44 +/- 7 PG/ml, and means = 87.33 +/- 14 PG/ml in those > 50 y. (P < 0.01). 80% of hypertensives < 50 y, had normal values of ANP (means = 63.8 +/- 10 PG/ml) and 20% high values (means = 131 +/- 6 PG/ml) (P < 0.001). 70% of hypertensives > 50 y, had high ANP values (means = 260 +/- 114 PG/ml) and 30% normal values (means = 75 +/- 5 PG/ml) (P < 0.001). Values for RAA were low or normal in 96% of cases with high ANP values (P < 0.001), and 100% of the cases with high RAA values, had low or normal ANP values. (P < 0.0001). This correlation had an statistically significant value for groups over 50 years (high ANP values, low RAA values) (P < 0.001) and high RAA values with low or normal ANP values in groups below 50 y (P < 0.001). We observed no significant correlation between ANP values and LVH. According to our results, essential hypertensives < 50 y, have low or normal ANP values in the majority of cases (P < 0.001). Essential hypertensives over 50 y. Have high ANP values also in the majority of cases (P < 0.001). As previously reported, an inversely proportional ratio between RAA and ANP was found in our study. The significance of ANP in regulating blood pressure in the elderly is considered.
心钠素（ANP）与肾素-血管紧张素-醛固酮系统（RAA）的比较。对6名年龄小于50岁的健康受试者、5名年龄大于50岁的健康受试者、44名年龄小于50岁的原发性高血压患者以及41名年龄大于50岁的原发性高血压患者进行了研究。年龄小于50岁的健康受试者的心钠素值，平均值为44±7皮克/毫升，而年龄大于50岁的受试者平均值为87.33±14皮克/毫升。（P<0.01）。年龄小于50岁的高血压患者中，80%的心钠素值正常（平均值为63.8±10皮克/毫升），20%的值偏高（平均值为131±6皮克/毫升）（P<0.001）。年龄大于50岁的高血压患者中，70%的心钠素值偏高（平均值为260±114皮克/毫升），30%的值正常（平均值为75±5皮克/毫升）（P<0.001）。在心钠素值偏高的病例中，96%的肾素-血管紧张素-醛固酮系统（RAA）值较低或正常（P<0.001），而肾素-血管紧张素-醛固酮系统（RAA）值偏高的所有病例，心钠素值均较低或正常。（P<0.0001）。这种相关性在50岁以上的人群中具有统计学意义（心钠素值高，肾素-血管紧张素-醛固酮系统值低）（P<0.001），在50岁以下的人群中，肾素-血管紧张素-醛固酮系统值高且心钠素值低或正常也具有统计学意义（P<0.001）。我们观察到心钠素值与左心室肥厚（LVH）之间无显著相关性。根据我们的研究结果，年龄小于50岁的原发性高血压患者，大多数情况下心钠素值较低或正常（P<0.001）。年龄大于50岁的原发性高血压患者，大多数情况下心钠素值也偏高（P<0.001）。正如之前所报道的，在我们的研究中发现肾素-血管紧张素-醛固酮系统（RAA）与心钠素（ANP）之间呈反比关系。研究了心钠素在调节老年人血压中的意义。
