1-氨基环丙烷-1-羧酸合酶、8-氨基-7-氧代壬酸合酶、2-氨基-6-己内酰胺消旋酶、2,2-二烷基甘氨酸脱羧酶、谷氨酸-1-半醛2,1-氨基变位酶和异青霉素-N-差向异构酶与转氨酶的同源性。
Homology of 1-aminocyclopropane-1-carboxylate synthase, 8-amino-7-oxononanoate synthase, 2-amino-6-caprolactam racemase, 2,2-dialkylglycine decarboxylase, glutamate-1-semialdehyde 2,1-aminomutase and isopenicillin-N-epimerase with aminotransferases.
作者信息
Mehta P K, Christen P
机构信息
Biochemisches Institut, Universität Zürich, Switzerland.
出版信息
Biochem Biophys Res Commun. 1994 Jan 14;198(1):138-43. doi: 10.1006/bbrc.1994.1020.
Profile analysis showed the title enzymes to be homologous with the aminotransferases. 1-Aminocyclopropane-1-carboxylate synthase is closely related to subgroup I of aminotransferases which includes aspartate, alanine, histidinol-phosphate, tyrosine and phenylalanine aminotransferase. 2,2-Dialkylglycine decarboxylase, glutamate-1-semialdehyde 2,1-aminomutase and 2-amino-6-caprolactam racemase are most similar to subgroup II which comprises aminotransferases with omega-amino acids as substrates. 8-Amino-7-oxononanoate synthase is closely related to both subgroup I and II, and isopenicillin-N-epimerase to subgroup IV with serine and phosphoserine aminotransferase. Aminotransferases and the title enzymes belong to a regio-specific family of evolutionarily related pyridoxal-5'-phosphate-dependent enzymes.
谱分析表明，标题中的酶与氨基转移酶同源。1-氨基环丙烷-1-羧酸合酶与氨基转移酶的第一亚组密切相关，该亚组包括天冬氨酸、丙氨酸、组氨醇磷酸、酪氨酸和苯丙氨酸氨基转移酶。2,2-二烷基甘氨酸脱羧酶、谷氨酸-1-半醛2,1-氨基变位酶和2-氨基-6-己内酰胺消旋酶与第二亚组最为相似，该亚组包含以ω-氨基酸为底物的氨基转移酶。8-氨基-7-氧代壬酸合酶与第一亚组和第二亚组都密切相关，而异青霉素N-表异构酶与第四亚组相关，包括丝氨酸和磷酸丝氨酸氨基转移酶。氨基转移酶和标题中的酶属于一个区域特异性家族，该家族由进化相关的依赖于磷酸吡哆醛-5'-磷酸的酶组成。
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